If you land in remote region, restart your city until you get in a more populated area (region and its neighbours). Do NOT delete your account to restart your city! Use the Start Again feature from the menu.
The default civics aren't very well suited for long term, try researching new ones as soon as possible.
Changing civics or doctrine will produce Anarchy which translates as great unhappiness and very high costs. Don't panic, Anarchy will only last a couple of hours.
Selling is caring! Caring for your treasury that is.
Travel speed propaganda is very useful when you trade a lot.
To increase chances of self-propaganda try raising your happiness temporary.
When the market of your main good is saturated be prepared for war.
Don't believe everything other players tell you, they have their own agenda.